| Document ID (ISN) | 100523 |
| CIS number |
02-1539 |
| Year |
1997 |
| Convention or series no. |
Toxikologische Bewertung Nr.198
|
| Title |
Phenyl isocyanate |
| Original title |
Phenylisocyanat [in German] |
| Bibliographic information |
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, Jan. 1997. 35p. 40 ref. |
| Abstract |
Workers exposed to isocyanates including phenyl isocyanate showed specific IgE for isocyanate-albumin conjugates. These workers also showed asthmatic symptoms. Animal experiments show the substance to be harmful upon oral administration. A low dermal toxicity and a high inhalation toxicity have been observed. Phenyl isocyanate induces severe skin and eye irritation and sensitization. No mutagenic or embryotoxic activity has been observed. A comparison of the toxic effects of 4-chlorophenyl isocyanate, phenyl isocyanate and 4-isopropylphenyl isocyanate in humans and animals is also presented. In humans, the only toxic effect described is an itchy erythema after repeated contact with chlorophenyl isocyanate. |
| Descriptors (primary) |
Germany; toxicity evaluation; pesticides; phenyl isocyanate |
| Descriptors (secondary) |
toxic effects; literature survey; criteria document; animal experiments; irritants |
| Document type |
B - Chemical safety information sheets |
| Country / State or Province | Germany |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Isocyanates
Cyano compounds
|
