| Document ID (ISN) | 21223 |
| CIS number |
74-1313 |
| ISSN - Serial title |
0004-1254 - Arhiv za higijenu rada i toksikologiju |
| Year |
1973 |
| Convention or series no. |
|
| Author(s) |
Pleština R., Svetličić B. |
| Title |
Toxic effects of two carbamate insecticides in dogs. |
| Bibliographic information |
1973, Vol.24, No.3, p.217-225. Illus. 19 ref. |
| Abstract |
The authors observed a difference in duration of plasma cholinesterase inhibition in workers exposed to propoxur (2-isopropoxyphenyl methylcarbamate) and promecarb (3-methyl-5-isopropylphenyl-N-methylcarbamate). To find out whether this difference is due to the enzyme-inhibitor interaction or to differences in absorption, they administered equitoxic doses of the 2 carbamates to dogs by intravenous and intramuscular injections. While a difference in inhibition duration was found only after intramuscular injection, the enzyme activity recovery was similar for both carbamates after intravenous injection. The delayed plasma cholinesterase recovery after promecarb administration was due to the much slower absorption of the compound after intramuscular injection. |
| Descriptors (primary) |
carbamates; toxicology; insecticides; enzyme disturbances |
| Descriptors (secondary) |
metabolic process; animal experiments; promecarb; arprocarb |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Blood diseases
Amides
|
