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CISDOC database
| Document ID (ISN) | 22502 |
| CIS number |
75-428 |
| ISSN - Serial title |
0091-6765 - Environmental Health Perspectives |
| Year |
1973 |
| Convention or series no. |
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| Author(s) |
Schwetz B.A., Norris J.M., Sparschu G.L., Rowe V.K., Gehring P.J., Emerson J.L., Gerbig C.G. |
| Title |
Toxicology of chlorinated dibenzo-p-dioxins. |
| Bibliographic information |
Research Triangle Park, USA, Sep. 1973, Experimental issue No.5, p.87-99. 17 ref. |
| Abstract |
Experiments were carried out using various animal species to evaluate the toxicity of some chlorinated dibenzodioxins. The compounds used were: 2,7-dichlorodibenzo-p-dioxin (2,7-DCDD); 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD); 1,2,3,4-tetrachlorodibenzo-p-dioxin (1,2,3,4-TCDD); hexachlorodibenzo-p-dioxin (HCDD); and octachloro-dibenzo-p-dioxin (OCDD). Tests were conducted to estimate acute lethality, acnegenic activity, teratogenicity, embryotoxicity and eye irritative effects. Some gross pathological and histopathological examinations were performed. The results show that: 2,3,7,8-TCDD has an unusually high toxicity; 2,7-DCDD and OCDD have a low toxicity; HCDD is highly toxic but less toxic than 2,3,7,8-TCDD; isomers of the same dibenzo-p-dioxin vary in toxicological properties, making it important to identify them specifically. |
| Descriptors (primary) |
chlorinated condensed hydrocarbons; toxicology; dioxins |
| Descriptors (secondary) |
embryotoxic effects; hexachlorodibenzo-p-dioxin; 2,7-dichlorodibenzo-p-dioxin; teratogenic effects; tetrachlorodibenzodioxin; 1,2,3,4-tetrachlorodibenzo-p-dioxin; animal experiments; octachlorodibenzo-p-dioxin |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
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| Broad subject area(s) |
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| Browse category(ies) |
Toxicology
Halogenated hydrocarbons
Heterocyclic compounds
Genetic factors in reaction to exposures
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