| Document ID (ISN) | 23441 |
| CIS number |
75-1370 |
| ISSN - Serial title |
0003-9896 - Archives of Environmental Health |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Drew R.T., Laskin S., Kuschner M., Nelson N., Capiello V. |
| Title |
Inhalation carcinogenicity of alpha halo ethers. |
| Bibliographic information |
Feb. 1975, Vol.30, No.2, p.61-77. Illus. 45 ref. |
| Abstract |
A series of 3 articles reporting the results of experimental studies in rats and hamsters on: I. acute inhalation of chloromethyl methyl ether (CMME) and bis(chloromethyl)ether (BCME); II. lifetime inhalation studies with a CMME concentration of 1ppm; and III. lifetime and limited exposures to 0.1ppm of BCME. The results of these studies identify BCME as an extremely potent respiratory carcinogen and commercial grade CMME as a definite carcinogen although of a lower order of activity than BCME, its toxicity possibly being due to contamination with BCME and formation of the latter after hydrolysis. |
| Descriptors (primary) |
carcinogens; inhalation toxicity; halogenated ethers |
| Descriptors (secondary) |
acute toxicity; chloromethyl methyl ether; chronic toxicity; animal experiments; bis(chloromethyl) ether |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Ethers
|
