| Document ID (ISN) | 25115 |
| CIS number |
76-1009 |
| ISSN - Serial title |
0009-0573 - Československá hygiena |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Barlogová S., Grunt J. |
| Title |
Sensitising properties of some pyridazine compounds |
| Original title |
Sensibilizačné vlastnosti niektorých pyridazinónových zlúčenin [in Slovak] |
| Bibliographic information |
Jan. 1975, Vol.20, No.1, p.5-9. 11 ref. |
| Abstract |
The sensitising effects of 2-phenyl-4,5-dichloro-3-pyridazinone (PCC) and its analogues 2-methyl-4,5-dichloro-3-pyridazinone (MCP) and 2-methyl-4,5-dimethoxy-3-pyridazinone (MMP) were tested experimentally on guinea pigs. These substances were administered in 3 different ways: repeated applications to the surface of the skin, a single intradermal injection with Freund's adjuvant (complete) in the digital pads. Administration of MMP produced no hypersensitisation, whereas administration of PCC and MCP in primarily non-toxic doses resulted in a delayed-type hypersensitivity, the intensity of which was dose-dependent. The antigenic determinant in PCC seems to be the phenyl radical, and in MCP it would appear to be chlorine. |
| Descriptors (primary) |
pyridazine derivatives; sensitization; pesticides |
| Descriptors (secondary) |
4,5-dimethoxy-2-methyl-3-pyridazinone; 4,5-dichloro-2-methyl-3-pyridazinone; dose-response relationship; animal experiments; hypersensitivity; 4,5-dichloro-2-phenyl-3-pyridazinone |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Heterocyclic compounds
Agricultural chemicals
|
