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CISDOC database
| Document ID (ISN) | 27658 |
| CIS number |
77-1415 |
| ISSN - Serial title |
0004-1254 - Arhiv za higijenu rada i toksikologiju |
| Year |
1976 |
| Convention or series no. |
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| Author(s) |
Muačević G. |
| Title |
Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos. |
| Bibliographic information |
1976, Vol.27, No.1, p.3-14. Illus. 11 ref. |
| Abstract |
The acute dermal toxicity, neurotoxicity, eye mucosa compatibility and cholinesterase inhibition of the insecticide was tested in animals. The oral, LD50 values obtained are: rat, 13mg/kg; mouse, 141mg/kg; guinea-pig, 58mg/kg; rabbit, 20mg/kg; quail, 45mg/kg; hen, 45mg/kg; and dermal LD50 for: rat, 58mg/kg and for rabbit, 48mg/kg. No signs of neurotoxicity in hens were observed. In rats, a maximal inhibition of erythrocyte cholinesterase was found after 2h, of plasma cholinesterase after 4 and of brain cholinesterase after 6h, with a reversal to normal in the blood observed after 4 days and in brain after 8 days. Lindane and phenobarbital pretreatment reduced the acute toxicity of chlorthiophos. Atropine, obidoxime chloride and trimedoxime bromide antagonised the toxic effects of chlorthiophos. |
| Descriptors (primary) |
chlorthiophos; cholinesterase; toxicology; insecticides; enzyme disturbances |
| Descriptors (secondary) |
neurotoxic effects; antagonistic effects; lindane; obidoxime; 2-pam(cl); dermal toxicity; phenobarbital; antidote treatment; animal experiments; lethal dose 50; trimedoxime |
| Document type |
- |
| Subject(s) |
Agriculture, fishing, animal husbandry
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| Broad subject area(s) |
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| Browse category(ies) |
Agricultural chemicals
Blood diseases
Esters and salts
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