| Document ID (ISN) | 29272 |
| CIS number |
78-769 |
| ISSN - Serial title |
0032-6291 - Pracovní lékařství |
| Year |
1977 |
| Convention or series no. |
|
| Author(s) |
Kopecký J., Šmejkal J., Krivucová M. |
| Title |
Toxicity of calcium salts of 2-dithiocarbamoylcarboxylic acids |
| Original title |
Toxicita vápenatých solí některých 2-dithiokarbaminokarboxylových kyselin [in Czech] |
| Bibliographic information |
Mar. 1977, Vol.29, No.3, p.85-88. 22 ref. |
| Abstract |
Carbon disulfide reacts with amino acids in the body to produce toxic dithiocarbamoylcarboxylic acids. In these animal studies on the metabolism and toxic effects of carbon disulfide, calcium dithiocarbamate derivatives of glycine, DL- and L-alanine, DL- and L-glutamic acid, L-tryptophan, and DL- and L-methionine were prepared. The intravenous LD50 of these salts and of carbon disulfide was determined. The toxicity of the salts was higher than that of carbon disulfide. Toxicity was inversely proportional to the molecular weight: thus calcium dithiocarbamoylacetate was about 6 times more toxic than carbon disulfide. The calcium salts were generally slightly less toxic when formed from L- than from DL-amino acids. |
| Descriptors (primary) |
esters and salts; toxicology; dithiocarbamates; carbon disulfide |
| Descriptors (secondary) |
metabolic process; animal experiments; toxicity evaluation |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Inorganic sulfur compounds
Esters and salts
Amides
|
