|
|
 |
|
|
CISDOC database
| Document ID (ISN) | 36844 |
| CIS number |
82-218 |
| ISSN - Serial title |
0098-4108 - Journal of Toxicology and Environmental Health |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Umetsu N., Mallipudi M.N., Toia R.F., March R.B., Fukuto T.R. |
| Title |
Toxicological properties of phosphorothioate and related esters present as impurities in technical organophosphorus insecticides |
| Bibliographic information |
Mar.-Apr. 1981. Vol.7, No.3-4, p.481-497. Illus. 21 ref. |
| Abstract |
When administered orally to rats at single doses of ≥15mg/kg 0,0,S-trimethyl phosphorothioate (TMP), an impurity in technical-grade malathion, caused delayed death 4-22 days after treatment. Mice were less sensitive to TMP than rats but similar effects were observed. TMP-treated rats refused food and water within 24hours of administration and up to the time of death. Intoxication was not blocked or reduced by injection of nutrient solution or atropine. 0,0,0-trimethyl phosphorothioate (0-TMP) was a potent antagonist to TMP and 1% 0-TMP protected rats from the intoxicating effects of TMP at doses ≤200mg/kg. The duration of inhibition of serum carboxylesterase and cholinesterase, caused by TMP, was significantly less when the toxicant contained 1% 0-TMP. 0,0,S-triethyl phosphorothioate and 0,S,S-trimethyl phosphorodithioate, also malathion impurities, induced the same signs of intoxication as TMP but at higher doses. |
| Descriptors (primary) |
organic thiophosphates; malathion; toxicology; pesticides |
| Descriptors (secondary) |
toxic effects; O,S,S-trimethyl dithiophosphate; O,O,S-trimethyl thiophosphate; insecticides; O,O,O-trimethyl thiophosphate; lethal dose 50; impurities; O,O,S-triethyl thiophosphate; animal experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Agriculture, fishing, animal husbandry
|
| Broad subject area(s) |
|
| Browse category(ies) |
Esters and salts
Agricultural chemicals
|
|
|
|
|
|