| Document ID (ISN) | 37247 |
| CIS number |
82-457 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Buchet J.P., Lauwerys R., Roels H. |
| Title |
Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man |
| Bibliographic information |
Feb. 1981, Vol.48, No.1, p.71-79. Illus. 24 ref. |
| Abstract |
The urinary elimination of the metabolites of arsenic was followed up as a function of time in volunteers who ingested a single oral dose of arsenic (500µg) either as sodium arsenite (Asi), monomethylarsonate (MMA), or dimethylarsinate (DMA). The excretion rate increased in the order Asii, MMA, and DMA, respectively. With regard to the in vivo biotransformation, DMA is excreted unchanged; MMA is slightly (13%) methylated into DMA while roughly 75% of the arsenic excreted after ingestion of ASi is methylated arsenic (about 1/3 as MMA and about 2/3 as DMA). The results have direct implications for the monitoring of workers exposed to arsenic. |
| Descriptors (primary) |
arsenic; urinary metabolites; urinary excretion; toxicology |
| Descriptors (secondary) |
metabolic process; exposure tests; human experiments |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
|
| Browse category(ies) |
Arsenic and compounds
Inorganic substances
|
