| Document ID (ISN) | 40480 |
| CIS number |
83-1623 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1981 |
| Convention or series no. |
|
| Author(s) |
Pis'ko G.T., Tolstopjatova G.V., Tovstenko A.I. |
| Title |
Comparative study of the toxicity of 2-hydroxy-3,6-dichlorobenzoic acid by various routes of administration |
| Original title |
Sravnitel'noe izučenie toksičnosti 2-oksi-3,6-dihlorbenzojnoj kisloty pri različnyh putjah postuplenija v organizm [in Russian] |
| Bibliographic information |
Sep. 1981, No.9, p.55-56. 3 ref. |
| Abstract |
The herbicide intermediate 2-hydroxy-3,6-dichlorobenzoic acid had an LD50 for mice of 660mg/kg, for rats of 1562mg/kg and for guinea pigs of 1800mg/kg. The compound showed no cumulative or allergenic properties. When applied to the skin, the compound was absorbed and showed weak irritant action. Chronic exposure of rats to 5.23mg/m3 produced functional changes in the liver and central nervous system and immunological and metabolic disorders after 60-120 days. Intragastric administration of 3mg/kg produced these symptoms in 1 month. The compound also produced changes in the cell population of peripheral blood. Dose-response data support a maximum acceptable concentration of 1mg/l in workplace air and 0.15mg/l in water. |
| Descriptors (primary) |
threshold limit values; USSR; pesticide production; toxicology; dichlorohydroxybenzoic acids |
| Descriptors (secondary) |
herbicides; animal experiments; 3,6-dichloro-2-hydroxybenzoic acid |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Occupational exposure limits
Chemical industry
|
