| Document ID (ISN) | 41312 |
| CIS number |
84-393 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1982 |
| Convention or series no. |
|
| Author(s) |
Orlova T.M., Šaškina L.F., Ryndina S.E. |
| Title |
Assessing the skin absorption of some synthetic ¿strogens |
| Original title |
K ocenke kožno-rezorptivnogo dejstvija nekotoryh sintetičeskih ėstrogennyh gormonov [in Russian] |
| Bibliographic information |
June 1982, No.6, p.18-21. 8 ref. |
| Abstract |
Sinestrol, fosfestrol and diethylstilboestrol were applied as acetone solutions to skin patches on rats and guinea pigs (dose range 0.0001-1.0mg/kg). Diethylstilboestrol had the strongest feminising effect, with a minimum active dose (Limac) of 0.001mg/kg; fosfestrol and sinestrol were less active, with approximate Limac values of 0.01 and 0.005mg/kg, respectively. However, the activities of all 3 compounds at such levels make them hazardous to workers in the pharmaceutical industry, especially to women. Protective measures should include limitations on working hours in the presence of the compounds, improved personal protective equipment and medical surveillance. |
| Descriptors (primary) |
oestrogens; pharmaceutical industry; skin absorption |
| Descriptors (secondary) |
diethylstilboestrol; fosfestrol; women; limitation of exposure; animal experiments; sinestrol |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Pharmaceutical industry
|
